{"id":6154,"date":"2020-06-02T09:45:42","date_gmt":"2020-06-02T07:45:42","guid":{"rendered":"https:\/\/www.smith.care\/?page_id=6154"},"modified":"2025-07-08T12:28:08","modified_gmt":"2025-07-08T10:28:08","slug":"use-case-phep","status":"publish","type":"page","link":"https:\/\/www.smith.care\/en\/research\/use-case-phep\/","title":{"rendered":"Use Case PheP"},"content":{"rendered":"

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Methodical Use Case PheP<\/h2>\n

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Phenotyping pipeline to support clinical evaluation projects<\/h3>\n

[\/vc_column_text][vc_column_text]Through the Medical Informatics Initiative (MII) and the establishment of Data Integration Centers<\/a>, clinical care data from multiple sources in the Hospital Information System (HIS) are being made available for medical research. The result is a unique and rich pool of clinical data that is precisely defined across all participating sites. With the methodological Use Case Phenotyping Pipeline, or PheP for short, the SMITH Consortium supported the development, qualitative enrichment and evaluation of the data pool from 2018 to 2023. The project is led by the Leipzig University.[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620639409581{background-color: #f5f6f6 !important;}”][vc_column css=”.vc_custom_1620729400531{padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 0px !important;background-color: #ffffff !important;}”][qode_elements_holder number_of_columns=”two_columns”][qode_elements_holder_item vertical_alignment=”top” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5%”][vc_single_image image=”5265″ img_size=”full” qode_css_animation=””][\/qode_elements_holder_item][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”left” advanced_animations=”no” item_padding=”5%”][vc_column_text css=”.vc_custom_1703075859288{padding-bottom: 10% !important;}”]<\/p>\n

PheP Use Case<\/h3>\n

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Development of innovative methods for processing, extracting and structuring clinical care data for research and healthcare<\/h5><\/div>

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Provision of a platform for the execution of distributed analyses<\/h5><\/div>

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Development, qualitative enrichment and evaluation of the clinical data pool<\/h5><\/div>

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Participation of all university hospitals represented in SMITH under the leadership of the Leipzig University<\/h5><\/div>

<\/p><\/div><\/div><\/div>[\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620300459787{background-color: #f5f6f6 !important;}”][vc_column][qode_elements_holder number_of_columns=”one_column”][qode_elements_holder_item advanced_animations=”no” item_padding=”5% 0 0 0″][vc_column_text]<\/p>\n

The PheP idea: Enriching health data and making it best available to science<\/h4>\n

[\/vc_column_text][vc_empty_space height=”25px”][vc_column_text]PheP has provided tools and methods to use medical data in a privacy-compliant way and to address new types of questions. Over the course of five years, the methodological use case has laid the groundwork for several other MII projects. This required the creation of data sets that could be used for clinical epidemiological and health economic questions.[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text]Phenotyping was used in PheP to derive and provide further characteristics from identifiable characteristics of patients (phenotypes). In this way, certain laboratory values and medications can be used to indicate other diseases or to find suitable patients for participation in a study. The Terminology- and Ontology-based Phenotyping (TOP)<\/a> Junior Research Group emerged from this part of the project. Since 2021, the junior research group has been working on a software platform for modeling and executing phenotype algorithms. It is located at the Leipzig University and led by Dr. Alexandr Uciteli. PheP has supported the record linkage process, which is used to merge patient data from different information sources, such as health insurance companies or death data from civil registries.[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620300468619{background-color: #f5f6f6 !important;}”][vc_column][qode_elements_holder number_of_columns=”one_column”][qode_elements_holder_item advanced_animations=”no” item_padding=”3% 0 0 0″ item_padding_480_600=”3% 0 10% 0″ item_padding_480=”3% 0 10% 0″][vc_column_text]<\/p>\n

Making medical texts available for research<\/h4>\n

[\/vc_column_text][vc_empty_space height=”25px”][vc_column_text]However, too little clinical information is available as machine-readable records – a challenge for the implementation of the PheP project. In particular, referral letters, findings, and surgical reports contain valuable information such as diagnoses, medications, side effects, and laboratory data that can only be extracted using natural language processing (NLP) and semantic text analysis methods. The PheP-NLP project has developed new methods for extracting complex information such as diagnoses, findings, medications or side effects from text. The Jena University Language & Information Engineering Lab (JULIE Lab) in cooperation with companies in the field of language processing academically led the process. In a pilot project with the three university hospitals in Aachen, Jena and Leipzig, medical documents of more than 3,000 patients were analyzed. The experience gained has led to a new project that is unique in Germany: the German Medical Text Corpus (GeMTeX)<\/a> project. Together with 16 partners \u2013 including six university hospitals \u2013 it will build up by far the largest collection of German-language medical texts for NLP research.[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620300468619{background-color: #f5f6f6 !important;}”][vc_column][qode_elements_holder number_of_columns=”one_column”][qode_elements_holder_item advanced_animations=”no” item_padding=”3% 0 5% 0″ item_padding_480_600=”3% 0 10% 0″ item_padding_480=”3% 0 10% 0″][vc_column_text]<\/p>\n

The PheP Engine enables data protection compliant analysis<\/h4>\n

[\/vc_column_text][vc_empty_space height=”25px”][vc_column_text]The idea of distributed analysis became the technical basis for the implementation of comprehensive data use projects at the MII locations in the form of the “PheP Engine”. The secure technology of the PheP Engine enabled distributed analysis of semantically and technically standardized data at all sites. With distributed analysis, sensitive patient data remains in the clinic while the algorithms access the data. With this technology, different clinical questions can be addressed flexibly and in compliance with privacy regulations. Distributed analysis is used in several MII Projectathons beyond the consortia, for example in the cardiology data use project “NT-proBNP<\/a>“.[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=””]PheP was funded by the German Federal Ministry of Education and Research (BMBF) from 01.01.2018 to 31.05.2023 as part of the SMITH Consortium.[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620640186865{background-color: #f5f6f6 !important;}”][vc_column css=”.vc_custom_1692171272109{margin-bottom: 5% !important;background-color: #ffffff !important;}”][qode_elements_holder number_of_columns=”one_column”][qode_elements_holder_item advanced_animations=”no” item_padding_480_600=”3% 0 10% 0″ item_padding_480=”3% 0 10% 0″ item_padding=”1% 0″][vc_column_text css=”.vc_custom_1692179734408{padding-top: 0px !important;padding-right: 0px !important;padding-bottom: 0px !important;padding-left: 3% !important;}”]<\/p>\n

Major Publications:<\/h4>\n

[\/vc_column_text][qode_content_slider auto_rotate=”5″ direction_nav=”no” control_nav=”yes” control_nav_justify=”no” pause_on_hover=”yes”][qode_content_slider_item][vc_column_text css=”.vc_custom_1704371882349{padding-top: 3% !important;padding-right: 3% !important;padding-left: 3% !important;}”]Uciteli A, Beger C, Kirsten T, Meineke FA, Herre H:[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371891349{padding-right: 3% !important;padding-left: 3% !important;}”]Ontological representation, classification and data-driven computing of phenotypes.<\/em>[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371898328{padding-right: 3% !important;padding-bottom: 3% !important;padding-left: 3% !important;}”]In: J Biomed Semantics. 2020 Dec 21;11(1):15. doi: 10.1186\/s13326-020-00230-0. PMID: 33349245; PMCID: PMC7751121.[\/vc_column_text][\/qode_content_slider_item][qode_content_slider_item][vc_column_text css=”.vc_custom_1704371854183{padding-top: 3% !important;padding-right: 3% !important;padding-left: 3% !important;}”]Meineke FA, St\u00e4ubert S, L\u00f6be M, Uciteli A, L\u00f6ffler M:[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371867477{padding-right: 3% !important;padding-left: 3% !important;}”]Design and Concept of the SMITH Phenotyping Pipeline. <\/em>[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371875654{padding-right: 3% !important;padding-bottom: 3% !important;padding-left: 3% !important;}”]In: Stud Health Technol Inform. 2019 Sep 3;267:164-172. doi: 10.3233\/SHTI190821. PMID: 31483269.[\/vc_column_text][\/qode_content_slider_item][qode_content_slider_item][vc_column_text css=”.vc_custom_1704371915037{padding-top: 3% !important;padding-right: 3% !important;padding-left: 3% !important;}”]Hahn U, Matthies F, Lohr C, L\u00f6ffler M:[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371922709{padding-right: 3% !important;padding-left: 3% !important;}”]3000PA-Towards a National Reference Corpus of German Clinical Language.<\/em>[\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1704371929390{padding-right: 3% !important;padding-bottom: 3% !important;padding-left: 3% !important;}”]In: Stud Health Technol Inform. 2018;247:26-30. PMID: 29677916.[\/vc_column_text][\/qode_content_slider_item][\/qode_content_slider][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row][vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1613479948915{background-color: #e0f4fc !important;}”][vc_column][qode_elements_holder number_of_columns=”two_columns” columns_proportion=”25_75″][qode_elements_holder_item advanced_animations=”no” item_padding=”50px 0px” item_padding_480_600=”40px 0px 20px 0px” item_padding_480=”40px 0px 20px 0px”][vc_single_image image=”945″ alignment=”center” style=”vc_box_circle_2″ qode_css_animation=””][\/qode_elements_holder_item][qode_elements_holder_item vertical_alignment=”middle” horizontal_alignment=”center” advanced_animations=”no” item_padding=”50px 0px” item_padding_480_600=”0px 0px 40px 0px” item_padding_480=”0px 0px 40px 0px”][vc_column_text]<\/p>\n

“SMITH’s work addresses the current challenges of digitization. Through the sustainable use of health data in medical research, decisive steps are being taken to improve diagnosis, prevention and treatments. Healthcare can be taken to a new level.\u201c<\/em><\/p>\n

[\/vc_column_text][vc_empty_space][vc_column_text]<\/p>\n

Prof. Dr. Markus L\u00f6ffler<\/p>\n

Head of the SMITH Consortium
\nHead of the PheP Use Case
\nInstitute for Medical Informatics, Statistics and Epidemiology (IMISE) | Leipzig University<\/p>\n

[\/vc_column_text][\/qode_elements_holder_item][\/qode_elements_holder][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"

[vc_row css_animation=”” row_type=”row” use_row_as_full_screen_section=”no” type=”grid” angled_section=”no” text_align=”left” background_image_as_pattern=”without_pattern” z_index=”” css=”.vc_custom_1620300438259{background-color: #f5f6f6 !important;}”][vc_column][qode_elements_holder number_of_columns=”one_column”][qode_elements_holder_item advanced_animations=”no” item_padding=”5% 0″ item_padding_480_600=”20px 0px 20px 0px” item_padding_480=”20px 0px 20px 0px”][vc_column_text] Methodical Use Case PheP [\/vc_column_text][vc_empty_space height=”15px”][vc_column_text css=”.vc_custom_1703075791906{padding-bottom: 5% !important;}”] Phenotyping pipeline to support clinical evaluation projects [\/vc_column_text][vc_column_text]Through the Medical Informatics Initiative…<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":16159,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"full_width.php","meta":{"footnotes":""},"class_list":["post-6154","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/pages\/6154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/comments?post=6154"}],"version-history":[{"count":37,"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/pages\/6154\/revisions"}],"predecessor-version":[{"id":24765,"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/pages\/6154\/revisions\/24765"}],"up":[{"embeddable":true,"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/pages\/16159"}],"wp:attachment":[{"href":"https:\/\/www.smith.care\/en\/wp-json\/wp\/v2\/media?parent=6154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}